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BPC-157

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" AFTER 2.5 MONTHS
   ON TAVO BPC, I WAS
   ABLE TO AVOID A
   CAREER ENDING     
   SURGERY "

- NIKITA BORIS

Professional ballet dancer Minori Sakita has performed principal roles in Victoria Morgan’s, The Nutcracker, Cinderella and King Arthur’s Camelot, John Cranko’s Onegin, Andre Prokovsky’s The Three Musketeers, Derek Dean’s Strictly Gershwin, Balanchine’s Serenade, Who cares, and Septime Weber’s The Wizard of Oz. 

EVERYTHING YOU NEED, NOTHING YOU DON'T.

No Chemicals, No Heavy Metals, No Pesticides No Fillers,

No Artificial Colors,  No Artificial Flavors, No Unnecessary Crap.

What is BPC-157 Peptide

BPC-157 is a native gastric pentadecapeptide that is non-toxic and has profound healing potential.  Originally discovered in the digestive system where it safeguards the stomach lining from acid damage, it has demonstrated its healing capabilities beyond just the gut. Its wide-ranging therapeutic properties include enhancing healing in various hard and soft tissues, promoting blood vessel growth, improving blood clotting and boosting the immune system.

To comprehend how BPC-157 exerts such diverse effects, it is crucial to delve into its fundamental activities and how they synergistically contribute to its remarkable healing capabilities.

BODY PROTECTION COMPOUND  - 157

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Potent Anti Inflammatory

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Supports Gut Health

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Repairs Bone Tissue

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Repairs Brain Tissue

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Repairs Soft Tissue

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Promotes Healing of Liver

Benefits of BPC-157 Include:

● Potent anti-inflammatory

● Possesses neuro-protective properties, specifically modulating the serotonergic and dopaminergic systems

● Promotes angiogenesis and vasculogenesis

● Accelerates wound healing (e.g. muscle, ligament, tendon, nerve)

● Promotes cell survival under stress

● Maintains GI mucosal integrity

● Protects and prevents gastric ulcers

● Improves digestive function (IBS)

● Used in Inflammatory bowel disease (IBD) exacerbations/flares

● Protects liver from toxic insults (alcohol, antibiotics, etc) and promotes healing

● Repairs tissue; such as GIT, tendons, ligaments, brain, bone, etc

● Effective treatment for Traumatic brain injury (TBI)

● Protects and heals inflamed intestinal epithelium (Leaky Gut Syndrome)

How Does BPC-157 Facilitate Hard and
Soft Tissue Healing?

Tendon and ligament injuries pose challenges due to limited blood supply, hindering effective healing. BPC-157 demonstrates positive effects on tendon, ligament, and bone injuries in animal models. It enhances the production of growth factors such as basic fibroblast growth factor (bFGF), epidermal growth factor (EGF), and VEGF, which guide cells to the site of injury, accelerating the healing process[5].

Additionally, BPC-157 increases the number of growth hormone (GH) receptors in tendons. This action enables targeted GH action at the injured tendon, without elevating GH levels throughout the body, leading to enhanced musculoskeletal development and immune function[6].

 

- Cell Survival and BPC-157

In vitro experiments show that fibroblasts survive for longer in the presence of BPC-157. Fibroblasts survive about 1.5 times longer when BPC-157 is present[6]. Those cells also tend to be healthier and more active, in turn more capable of carrying out their repair roles.

 

- Fibroblast Outgrowth and Migration

Fibroblasts are motile cells found in most connective tissue (bones, tendons, muscle, gastric mucosa, skin, etc.). When damage to tissue occurs, fibroblasts migrate to the site of injury in order to start the repair process. They also divide and reproduce to increase the number of fibroblasts available for tissue repair.

In vitro studies show that migration of fibroblasts is directly affected by the amount of  BPC-157 present. Where higher levels of BPC-157 are found, higher amounts of  fibroblasts can also be found.

Evidence shows that BPC-157 doesn’t just attract, but that it actually causes fibroblasts to migrate nearly 2.5 times faster than normal. Not only do the cells migrate in response to BPC-157 levels, they reproduce in response to them as well. Fibroblast outgrowth is approximately three times higher in the presence of BPC-157[13].

 

- Fibroblasts and Genetic Modification

Animal test studies show that BPC-157 controls the functions of collagen fragments by promoting the work of fibroblasts, the cells responsible for collagen deposition and maintenance. These studies have revealed that BPC-157 influences fibroblasts by upregulating expression of the GH receptor gene. In other words BPC-157 alters the function of DNA.

Fibroblasts are found all throughout the body, and are especially active in connective tissue. BPC-157 boosts the GH response by increasing GH receptor density to the injured connective tissue. The result is that even with normal physiologic levels of GH, more is recruited to the site of injury causing healing to proceed at a faster rate. Ongoing testing and research is revealing more and more beneficial effects of BPC-157.

How Does BPC-157 Promote Blood Vessel Function?

Studies reveal that BPC-157 operates through two distinct mechanisms within blood vessels. Firstly, it aids in vasodilation, facilitating smoother blood flow, by elevating the levels of nitric oxide, a natural compound. Nitric oxide not only helps regulate blood pressure but also maintains the health of endothelial cells that line blood vessels.

Secondly, BPC-157 directly stimulates the growth of endothelial cells, thereby promoting blood vessel formation[1],[2]. It achieves this by increasing nitric oxide production within blood vessels and activating the vascular endothelial growth factor (VEGF), a growth factor that triggers endothelial cell division and growth. These findings suggest that BPC-157 induces favorable alterations in DNA expression patterns, supporting blood vessel growth and overall vascular health.

How Does BPC-157 Aid in Wound Repair?

BPC-157 accelerates wound healing by restoring blood flow to damaged tissues. This effect is observed in various tissues such as the stomach, heart, tendons, and skin. The peptide enhances blood vessel growth towards the site of injury, increasing blood circulation. Additionally, BPC-157 stimulates the migration of fibroblasts, cells responsible for generating the extracellular matrix crucial for initiating wound healing.

The peptide's ability to expedite wound repair is exemplified by its effectiveness in healing fistulas, which are notoriously difficult to treat. While traditional methods may take over two and a half years, BPC-157 achieves healing within a month in animal models[1],[3],[4].

Different Types of BPC-157

BPC-157 is available in two variants known as arginate and acetate salts. These variations are modifications made to ensure the stability of BPC-157 during transportation and storage. Acetate salts are easier and cheaper to produce but are less stable during transport and storage. On the other hand, arginate salts are more expensive to produce but have a longer shelf life.

 

The advantages of using arginate salts extend beyond storage and transport considerations. Research indicates that arginate salts are more resistant to gastric acid, with only 10% of the administered dose being degraded after 5 hours in stomach acid. In contrast, the acetate salt version loses 98% of its effectiveness within a few hours in stomach acid. This characteristic makes arginate salts more beneficial for studying the effects of orally administered BPC-157. The long-lasting nature of arginate salts allows them to remain intact even in the presence of stomach acid[10].

Synergistic effects of BPC-157 and TB4 Fragment (Ac-SDKP) 

The benefits of TB4 frag and BPC-157 generally arise from the fact that these two peptides affect the same cells in slightly different ways. TB4 frag boost cell migration and cell motility, this may sound trivial, but the ability of cells like fibroblasts to get to sites of injury is a rate limiting step in tissue repair. Many of these cells die before they reach their destination or simply don’t last long once they get there, so boosting their ability to move around is of massive benefit.  Combining the ability of cells to get to the site of injury with an ability to function better and for longer once they are there is a triple synergy. This is where BPC-157 builds on the benefits of TB4 frag. BPC-157 improves fibroblast cell function by increasing growth hormone receptor density, thus improving both the longevity of these cells and their ability to grow/divide during the healing process. The result is that more cells get to the site of tissue injury and they are healthy when they get there. Healthy cells not only do more work, they produce more offspring that can then also do more work. This is why combining TB4 frag with BPC-157 is likely not just an additive process, but a multiplicative process. The benefits build on one another to dramatically increase tissue repair following injury.

Synergy in Neurological Recovery

TB4 frag has been shown in animal models to encourage the growth and proliferation of both central and peripheral nervous system tissues following injury. It is thought that TB4 activates the cells that support neurons, allowing them to provide more nutrients to the damaged cells as they recover[C]. These studies have shown that TB4 administration leads to substantial improvements in behavior, motor control and cognitive impairment[D].

 

Research also indicates that TB4 frag can help to reduce oxidative stress and improve the recovery of neural stem cells. BPC-157 may play a similar role in the brain as research has shown that it protects somatosensory neurons from injury by reducing inflammation in the nervous system[E]. BPC-157 also plays a protective role in the central nervous system, helping it to prepare for damage before it happens. It isn’t clear how it achieves this function specifically, but it does play an important role in signaling from the GI system. Researchers think that it may act as an early warning molecule to the brain, letting it know that noxious damage is on the way so that it can prepare.  It is  believed that BPC-157 helps the brain to maintain homeostasis even in the setting of traumatic injury.

 

TB4 frag has been tested in animal models of multiple sclerosis and found to help decrease levels of inflammatory molecules in the brain. This results in reversal of demyelination, the hallmark of multiple sclerosis and a marker of disease severity[F]. This benefit is probably mediated by enhanced neural supportive cell migration.

Together, BPC-157 and TB4 frag could substantially impact the health of the nervous system by reducing inflammation and oxidative stress, protecting cells that support neurons, and improving migration of cells that are responsible for tissue repair.

Muscle Recovery and Bone Strength with BPC 157 and TB-4 Fragments (Ac-SDKP)

BPC-157 is an efficient promoter of tendon healing. Tendons are notoriously difficult to repair following injury and generally require surgical intervention to restore full function and range of motion[G]. Research shows that BPC-157 accelerates tendon repair by boosting fibroblast outgrowth and migration. Interestingly, BPC-157 also improves the quality of the repair.  BPC-157 not only speeds recovery of injured tendons but it improves the outcome such that the tendon is stronger and more functional than had BPC-157 not been administered[H].

 

TB4 frag is effective in speeding musculoskeletal recovery both following injury and following exercise. Because it speeds the rate of migration of cells, it would directly impact tendon repair where fibroblast migration has been observed to be slow and incomplete under natural circumstances.  The slow migration of immune cells and fibroblasts into tendons is at least in part because of poor blood supply. Both BPC-157 and TB4 frag are angiogenic and accelerate the growth of blood vessels. Together, these peptides can boost blood supply to injured tissue, particularly to tissue like tendons which have inadequate blood supply for healing. This not only speeds recovery by getting repair cells where they need to be, it improves the final outcome by increasing extracellular matrix deposition.

 

Another way in which BPC-157 and TB4 frag interact to help heal musculoskeletal injuries is boosting growth hormone. Research shows that BPC-157 increases the expression of growth hormone receptors on fibroblasts. Growth hormone is extremely important in musculoskeletal development and repair.  BPC-157 circumvents some side effects by boosting receptors rather than the hormone itself[I]. This leads to targeted benefits in tissue repair without as many traditional side effects. So, fibroblasts essentially receive a boost of growth hormone by expressing more receptors, which can lead to their proliferation and increase their longevity. Combined with the motility effects of TB4 frag, BPC-157 can enhance the function of fibroblasts. In other words, not only are there more repair cells to get the work done, the cells that are involved in the repair are more effective. The benefits stack up on one another to potentially supercharge the healing process.

At TAVO we manufacture our BPC-157 using arginate salt, to ensure you are getting the most beneficial product on the market. 

References

[1]T. Huang et al., “Body protective compound-157 enhances alkali-burn wound healing in vivo and promotes proliferation, migration, and angiogenesis in vitro,” Drug Des. Devel. Ther., vol. 9, pp. 2485–2499, 2015, doi: 10.2147/DDDT.S82030.

[2]S. A. Deek, “BPC 157 as Potential Treatment for COVID-19,” Med. Hypotheses, vol. 158, p. 110736, Jan. 2022, doi: 10.1016/j.mehy.2021.110736.

 

[3]P. Sikiric et al., “Novel Cytoprotective Mediator, Stable Gastric Pentadecapeptide BPC 157. Vascular Recruitment and Gastrointestinal Tract Healing,” Curr. Pharm. Des., vol. 24, no. 18, pp. 1990–2001, 2018, doi: 10.2174/1381612824666180608101119.

 

[4]M. Baric et al., “Stable gastric pentadecapeptide BPC 157 heals rectovaginal fistula in rats,” Life Sci., vol. 148, pp. 63–70, Mar. 2016, doi: 10.1016/j.lfs.2016.02.029.

 

[5]S. Seiwerth et al., “BPC 157 and Standard Angiogenic Growth Factors. Gastrointestinal Tract Healing, Lessons from Tendon, Ligament, Muscle and Bone Healing,” Curr. Pharm. Des., vol. 24, no. 18, pp. 1972–1989, 2018, doi: 10.2174/1381612824666180712110447.

 

[6]C.-H. Chang, W.-C. Tsai, Y.-H. Hsu, and J.-H. S. Pang, “Pentadecapeptide BPC 157 enhances the growth hormone receptor expression in tendon fibroblasts,” Mol. Basel Switz., vol. 19, no. 11, Art. no. 11, Nov. 2014, doi: 10.3390/molecules191119066.

 

[7]P. Sikiric et al., “Brain-gut Axis and Pentadecapeptide BPC 157: Theoretical and Practical Implications,” Curr. Neuropharmacol., vol. 14, no. 8, Art. no. 8, Nov. 2016, doi: 10.2174/1570159X13666160502153022.

 

[8]P. Sikiric et al., “Stable Gastric Pentadecapeptide BPC 157, Robert’s Stomach Cytoprotection/Adaptive Cytoprotection/Organoprotection, and Selye’s Stress Coping Response: Progress, Achievements, and the Future,” Gut Liver, vol. 14, no. 2, pp. 153–167, Mar. 2020, doi: 10.5009/gnl18490.

 

[9]S. Radeljak, S. Seiwerth, and P. Sikiric, “BPC 157 inhibits cell growth and VEGF signalling via the MAPK kinase pathway in the human melanoma cell line,” Melanoma Res., vol. 14, pp. A14–A15, Aug. 2004, doi: 10.1097/00008390-200408000-00050.

 

[10]R. Rucman, “Stable pentadecapeptide salts, a process for preparation thereof, a use thereof in the manufacture of pharmaceutical preparations and a use thereof in therapy,” US9850282B2, Dec. 26, 2017 Accessed: Jul. 23, 2020. [Online]. Available: https://patents.google.com/patent/US9850282B2/en

 

[11] “Wake Forest University Publishes Mechanism of Action Reseach.” H-Wave, 5 Oct. 2009, www.h-wave.com/blog/wake-forest-university-publishes-moa-reseach/.

 

[12] “Figure 3 the Physiological Roles of Nitric Oxide on Endothelial Function.” ResearchGate, www.researchgate.net/figure/The-physiological-roles-of-nitric-oxide-on-endothelial-function_fig1_267335644.    

 

[13] T. Cerovecki, I. Bojanic, L. Brcic, B. Radic, I. Vukoja, S. Seiwerth, and P. Sikiric, "Pentadecapeptide BPC 157 (PL 14736) improves ligament healing in the rat," J. Orthop. Res. Off. Publ. Orthop. Res. Soc., vol. 28, no. 9, pp. 1155-1161, Sep. 2010.

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Embrace the transformative capabilities of BPC-157 peptide and unlock the full potential of your body's healing mechanisms.

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